We conducted conventional and cumulative metaanalyses using the common dersimonianlaird random effects model. It can be used to pull results from two or three of the channing cohorts and test for betweenstudies heterogeneity. For a short overview of meta analysis in medcalc, see meta analysis. Although clinical trial registries have been established to reduce nonpublication, the results from over half of all trials registered in clinicaltrials.
Aggregate data metaanalysis is currently the most commonly used method for combining the results from different studies on the same outcome of interest. Dersimonian and laird proposed an approximation method to estimate the value of. May 24, 2012 this macro produces the laird and dersimonian estimators for. This produces a randomeffects metaanalysis, and the simplest version is known as the dersimonian and laird method dersimonian 1986. Forestpmplot is a free, opensource a pythoninterfaced r package tool for analyzing the heterogeneous studies in meta analysis by visualizing the. To account for potential study variance, we performed a dersimonian laird randomeffects model meta analysis of extracted data using the metan package in stata statistical software. The dersimonian laird randomeffects model was employed to estimate the overall prevalence. Hence we have marginal normality and the conventional model random effects model.
The attraction of this method is that the calculations are straightforward, but it has a theoretical disadvantage that the confidence intervals are slightly too narrow to encompass full uncertainty resulting from having estimated the degree of heterogeneity. Methods to estimate the betweenstudy variance and its. Evaluate study heterogeneity with subgroup analysis or meta regression. A variation on the inversevariance method is to incorporate an assumption that the. Aug 12, 2017 the confidence interval of the overall effect is automatically based on the knapp. Meta analysis of antibacterial catheter coating cochrane. How does the dersimonian and laird procedure for random effects. Now thirty years on, randomeffects meta analysis models remain hugely popular and are increasingly relevant due to the large volume of medical research available across heterogeneous populations and. Comprehensive metaanalysis is easy to learn and use, with a clear and friendly interface. Meta analysis is a statistical methodology that combines or integrates the results of several independent clinical trials considered. The statistical software newsletter metaanalysis macros. This is most common random effects model used in meta analysis.
Meta analysis is a statistical methodology that combines or integrates the results of several independent clinical trials considered by the analyst to be combinable huque 1988. In a meta analysis of only a few studies, with each study having a diverse sample and effect size, the dl method can lead to biased. It offers you a broad range of statistical, analytical and graphic capabilities to ensure valid meta analysis. Dersimonian and laird randomeffects models are used. Recommended softwarepackages for metaanalysis of diagnostic. Cdclogo dersimonian and laird univariate meta analysis. Aug 26, 2012 comprehensive meta analysis, a statistical software package developed specifically for ad meta analysis, allows the user to conduct randomeffects analysis using the method of moments and maximum likelihood approaches.
Corporate pricing comprehensive metaanalysis software cma. For inverse variance approaches, differences are more common for smaller meta analyses and the methods agree more often in meta. In the random effects model, the weight assigned to study i is. Meta analysis for psychiatric research using free software r. Dersimonian and laird proposed an approximation method to estimate the value of d2 that is easy enough to do in microsoft excel as well as a test for whether there is heterogeneity in the effect between studies. A metaanalysis is a statistical analysis that combines the results of multiple scientific studies. A variation on the inversevariance method is to incorporate an assumption that the different studies are estimating different, yet related, intervention effects. Features in detail professional software for metaanalysis. Comprehensive meta analysis is easy to learn and use, with a clear and friendly interface.
It emphasizes the practical importance of the effect size instead of the statistical significance of individual studies. Both methods provide the same summary estimate and suggest that ripc offers no statistically significant reduction in aki or acute dialysis figure 2. The historical roots of meta analysis can be traced back to 17th century studies of astronomy, while a paper published in 1904 by the statistician karl pearson in the british medical journal which collated data from several studies of typhoid inoculation is seen as the first time a meta analytic approach was used to aggregate the outcomes of multiple clinical studies. The attraction of this method is that the calculations are straightforward. The commonly used method for a random effects meta analysis is the dersimonian and laird approach dl method. Assess the impact of publication bias on results with trimandfill analysis. Methods to estimate the between study variance and to calculate.
The accessibility of the dersimonian laird dl method and its inclusion in common meta analysis software such as revman6 has led to it being the most common method for using random effects in meta analyses, and it is a fairly reliable approximation when the number of studies is large. The dersimonian and laird method, which assumes heterogeneity across studies, is the most common method for using a randomeffects model in the meta analysis 14, 15. The most widely used method to estimate between studies variance revc is the dersimonianlaird dl approach. Here it is shown that, unless all studies are of similar size, this is inefficient when estimating the betweenstudy variance, but is remarkably efficient when estimating the treatment effect. This shift in thinking has been termed metaanalytic thinking. For random models, dersimonian and laird randomeffects models are used. Forest plots, funnel plots and labbe plots can be drawn and statistical tests for funnel plot asymmetry can be computed. Since then, the statistical methods evolved from simply following the approaches used for intervention meta analyses to the summary roc sroc model also known as moseslittenberg model which takes in to account the threshold effect, and then to more advanced. The procedure suggested by dersimonian and laird is the simplest and most commonly used method for fitting the random effects model for meta analysis. Besides the standard dersimonian and laird approach.
When either inverse variance method is selected, a forest plot is displayed and also heterogeneity statistics are included in the output to indicate which. This paper presents a selection of likelihood and nonlikelihood methods for inference in meta analysis proposed to overcome the limitations of the dersimonian and laird procedure, with a. The confidence interval of the overall effect is automatically based on the knapp. The dersimonian and laird 1986 dl method is the most commonly implemented approach and is the default approach in many software routines. This macro produces the laird and dersimonian estimators for. To account for potential study variance, we performed a dersimonian laird randomeffects model meta analysis of extracted data using the metan package in stata statistical software version 15. Despite these shortcomings, the dersimonianlaird procedure dl is the default method in many metaanalysis software programs. To carry out random effects analysis using the approach of dersimonian and laird dsl, controlled clinical trials, 1986,7,177188 and also using that of hardy and thompsonht, statistics in medicine. This is a fully functional version, except users cannot create or load custom datasets. Mantel n, haenszel w 1959 statistical aspects of the analysis of data from the retrospective analysis of disease. Statsdirect first transforms proportions via the freemantukey double arcsine method murray et al. Dersimonian and laird twostep starting with cochran anova. Request pdf how does the dersimonian and laird procedure for random effects metaanalysis compare with its more efficient but harder to compute.
A meta analysis addin for microsoft excel abstract. Diagnostic odds ratio truefalse a db c in order to run a meta. We conducted conventional and cumulative meta analyses using the common dersimonian laird random effects model. How does the dersimonian and laird procedure for random. The dersimonian and laird method is the only randomeffects method commonly available in metaanalytic software. The jasp metaanalysis module was supported by a ssmart grant from the. Meta analysis in medical research dersimonian and laird 1986 noted, almost 15 years ago, that meta analysis is becoming popular in medical research where information on efficacy of a treatment is available from a number of clinical studies with similar treatment protocols. Similarly, when there is little information, either because there are few studies or if the studies are small, a randomeffects analysis will provide poor estimates of the width of the distribution of intervention effects. Dersimonianlaird, hedges, sidikjonkman, and hunterschmidt. Metaanalysis for psychiatric research using free software r. Higgins jp, thompson sg, deeks jj, altman dg 2003 measuring inconsistency in meta analyses. Several meta analysis software packages are currently available.
Comprehensive meta analysis version 2 is really an easytouse software. Aggregate data metaanalysis is currently the most commonly used method. However, the great majority focus on meta analysis of clinical trials as it is the field where meta analysis is used more routinely. Publication bias assessed by the funnel plot and more objectively by eggers regression test. The most commonly used methods are dersimonianlaird. Meta analysis in clinical trials rebecca dersimonian and nan laird abstract. Metaanalysis statistical software jmp software from sas. The 1986 paper meta analysis in clinical trials by dersimonian and laird was a breakthrough for the application of randomeffects meta analysis. Psychology and mental health technology application open source software usage psychiatric research public software. For a short overview of metaanalysis in medcalc, see metaanalysis. Besides the stan dard dersimonian and laird approach, metaan. The accessibility of the dersimonianlaird dl method and its inclusion in common metaanalysis software such as revman6 has led to it being the most common method for using random effects in metaanalyses. The actual coverage probabilities of nominal 95% confidence intervals for the treatment effect obtained using dersimonian and laird s procedure with both standard normal and t quantiles and the likelihood approach to random effects meta analysis are shown in table 1, for n 4, 8, 16, 32 and a range of i 2 values. An application of metaanalysis based on dersimonian and laird.
The engine behind this analysis power is the software developed in the metaforproject. The software provides a detailed display of metaanalytic results plus a wonderful format for presentation of results. The fixed effect model assumes that this variance is 0. Revman implements a version of randomeffects metaanalysis that is described by dersimonian and laird dersimonian 1986. Metasoft is a free, opensource meta analysis software tool for genomewide association study analysis, designed to perform a range of basic and advanced meta analytic methods in an efficient manner. Pg reported effect size using the dersimonian laird dl method. These random effects models and software packages mentioned above relate to studyaggregate. Pdf this article describes the new metaanalysis command metaan, which can be. Randomeffects model for metaanalysis of clinical trials. The dersimonian and laird method, currently widely used by default to estimate the. The principal summary statistic was or with 95% confidence intervals. Introduction meta analysisis a statistical technique that allows an analyst to combine effect sizes across multiple studies into one meaningful estimate. In a metaanalysis of only a few studies, with each study having a diverse sample and effect size, the dl method can lead to biased.
When the random effects model is selected, the weights include an estimate of the betweenstudy variance dersimonian and laird, 1986. Nov 15, 2017 these include fixed and random effects analysis, fixed and mixed effects meta regression, forest and funnel plots, tests for funnel plot asymmetry, trimandfill and failsafe n analysis, and more. This produces a randomeffects metaanalysis, and the simplest version is known as the dersimonian and laird method dersimonian. Metaanalysis with linear and nonlinear multilevel models. In the dersimionian laird method, the heterogeneity. A good example of this orientation is the software package easyma, recently presented in this journal, where the input must be raw data. It is my favorite software for metaanalysis of studylevel data.
It has been almost 30 years since the publication of the first meta analysis of diagnostic test accuracy dta. Metaanalysis in jasp free and userfriendly statistical software. Use funnel plots and formal tests to explore publication bias and smallstudy effects. For statistical models, both fixed model and random model are included in the revman. The procedure suggested by dersimonian and laird is the simplest and most commonly used method for fitting the random effects model for metaanalysis. However, its default use has often been challenged in. Isquared statistics was used to check the heterogeneity of the studies. Biostatistics in psychiatry 27, report by shanghai archives of psychiatry. Jonkman, restricted maximum likelihood, or empirical bayes. Association of maternal lactation with diabetes and. We would suggest that incorporation of heterogeneity into an estimate of a treatment effect should be a secondary consideration when attempting to produce estimates of effects from sparse data the primary concern is to discern. An application of metaanalysis based on dersimonian and. Metaanalysis leads to a shift of emphasis from single studies to multiple studies.
The hartungknappsidikjonkman method for random effects. The software provides a detailed display of meta analytic results plus a wonderful format for presentation of results. It is meant for those wanting to learn or teach about meta analysis. Dersimonian r, laird n 1986 meta analysis in clinical trials. Both methods provide the same summary estimate and. The differences in the statistical conclusions between the standard methods and the dersimonian laird bootstrap, by meta analysis size, are presented in tables s4 to s6 in file s1. In this paper, we provide a brief introduction to metaanalysis, including a description of aggregate and individual participant data metaanalysis.
It can be used to pull results from two or three of the. Hivaids treatment failure and associated factors in. Revman implements a version of randomeffects meta analysis that is described by dersimonian and laird dersimonian 1986. This article describes the new meta analysis command metaan, which can be used to perform fixed or randomeffects meta analysis. Raw data counts or summary data adjusted or, rr or rd can be used as input. The results of a metaanalysis are often shown in a forest plot. The commonly used method for a random effects meta analysis is the dersimonian and laird approach dl method 1. While the original dersimonian and laird randomeffects model is the. The accessibility of the dersimonianlaird dl method and its inclusion in common metaanalysis software such as revman6 has led to it being the most common method for using random effects in metaanalyses, and it is a fairly reliable approximation when the number of studies is large.
1676 601 908 272 1062 304 1607 263 327 596 634 326 1620 1452 793 100 773 1501 1516 1137 57 1165 148 642 1592 83 729 656 853 1308 219 560 1009 285 247 961 522 782 235 1372